Approximating Hessians in multilevel unconstrained optimization V. Malmedy and Ph. L. Toint Report 08/19 December 2008 Abstract. We consider Hessian approximation schemes for large-scale multilevel unconstrained optimization problems, which typically present a sparsity and partial separability structure. This allows iterative quasi-Newton methods to solve them despite of their size. Structured finite-difference methods and updating schemes based on the secant equation are presented and compared numerically inside the multilevel trust-region algorithm proposed by Gratton, Mouffe, Toint and Weber (2008).